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Sigma-Aldrich A9809 Amsacrine hydrochloride) ≥98% (TLC), powder 50 mg

Stok Kodu
LB.SA.A9809-50MG
Kısa Bilgi
Synonym(s): 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride, m-AMSA Empirical Formula (Hill Notation): C21H19N3O3S · HCl CAS Number: 54301-15-4 Molecular Weight: 429.92 MDL number: MFCD07799963 PubChem Substance ID: 24278248 NACRES: NA.77
Bilgi
CAS Number: 54301-15-4
Ön Siparişli Ürün
Sigma-Aldrich A9809 Amsacrine hydrochloride) ≥98% (TLC), powder 50 mg
Synonym(s): 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride, m-AMSA
Empirical Formula (Hill Notation):
C21H19N3O3S · HCl
CAS Number:
54301-15-4
Molecular Weight:
429.92
MDL number:
MFCD07799963
PubChem Substance ID:
24278248
NACRES:
NA.77
Sigma-Aldrich A9809 Amsacrine hydrochloride) ≥98% (TLC), powderSigma-Aldrich A9809 Amsacrine hydrochloride) ≥98% (TLC), powderSigma-Aldrich A9809 Amsacrine hydrochloride) ≥98% (TLC), powderSigma-Aldrich A9809 Amsacrine hydrochloride) ≥98% (TLC), powder     
PROPERTIES
Quality Level 200
Assay
≥98% (TLC)
form
powder
color
red to brown
mp
197-199 °C (lit.)
solubility
DMSO: 10 mg/mL (with heat and sonication), 30% ethanol: 4 mg/mL
storage temp.
room temp
SMILES string
Cl.COc1cc(NS(C)(=O)=O)ccc1Nc2c3ccccc3nc4ccccc24
InChI
1S/C21H19N3O3S.ClH/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21;/h3-13,24H,1-2H3,(H,22,23);1H
InChI key WDISRLXRMMTXEV-UHFFFAOYSA-N
Gene Information
human ... TOP2A(7153) , TOP2B(7155)


DESCRIPTION
Application
Amsacrine hydrochloride has been used:
- as a topoisomerase poison in bacteriophage T4 topoisomerase assay[1]
- as a topoisomerase inhibitor in Drosophila cell line, Kc167 [2]
- as an antileukemia drug to test its effect on p53 transcriptional activity in tumor xenografts[3]
-as a topoisomerase II poison in dose-response assays in C elegans[4]
Biochem/physiol Actions
Amsacrine (m-AMSA) is a derivative of acridine[5] and an antileukemia drug.[3] It is an anticancer drug with antineoplastic activity that targets topoisomerase II.[5] AMSA is an apoptosis inducer[6] and favors the accumulation of double-stranded breaks (DSBs).[2] It also inhibits the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 expression in leukemia cells by generating reactive oxygen species (ROS). AMSA serves as an adjuvant in trabeculectomy surgery.[6] Amsacrine hydrochloride is a DNA topoisomerase II inhibitor.

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Sigma-Aldrich 156264 Ammonium formate reagent grade, 97%
Sigma-Aldrich A9809 Amsacrine hydrochloride) ≥98% (TLC), powder 50 mg Empirical Formula (Hill Notation): C21H19N3O3S · HCl CAS Number: 54301-15-4 Molecular Weight: 429.92 MDL number: MFCD07799963 PubChem Substance ID: 24278248 NACRES: NA.77 LB.SA.A9809-50MG
Sigma-Aldrich A9809 Amsacrine hydrochloride) ≥98% (TLC), powder 50 mg

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