Merck 108219 Tris(hydroxymethyl)aminomethane hydrochloride EMPROVE® EXPERT 1 kg

Category

Analitik Kimyasallar

Brand

MERCK

Stock Code

LB.M.1082191000

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Merck 108219 Tris(hydroxymethyl)aminomethane hydrochloride EMPROVE® EXPERT 1 kg
Catalogue Number	108219
Synonyms	Trometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer
Description	Tris(hydroxymethyl)aminomethane hydrochloride

Merck 108219 Tris(hydroxymethyl)aminomethane hydrochloride EMPROVE® EXPERT

Product Information
CAS number	1185-53-1
EC number	214-684-5
Hill Formula	C₄H₁₁NO₃˙ ClH
Chemical formula	C₄H₁₁NO₃*ClH
Molar Mass	157.60 g/mol
HS Code	2922 19 00
Structure formula Image
Quality Level	MQ500

Physicochemical Information
Density	1.28 g/cm3 (20.2 °C)
Melting Point	150.7 °C
pH value	4.2 (100 g/l, H₂O, 20 °C)
Vapor pressure	<0.1 hPa (50 °C)
Solubility	561 g/l soluble

Safety Information according to GHS
Storage class	10 - 13 Other liquids and solids
WGK	WGK 1 slightly hazardous to water
Disposal	3 Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.

Storage and Shipping Information
Storage	Store at +15 °C to +25 °C.

Specifications
Appearance (color)	white to almost white
Appearance (description)	crystalline powder
Assay (Perchloric acid titration, calc. on anhydrous substance)	≥ 99.0 %
Identity (IR-spectrum)	conforms
pH-value (0.5 mol/l, water)	3.5 - 5.0
Melting range	147 - 153 °C
UV-Absorption (230 nm; 10 %; 1 cm; water)	≤ 0.1
UV-Absorption (260 nm; 10 %, 1 cm; water)	≤ 0.06
UV-Absorption (280 nm; 10 %; 1 cm; water)	≤ 0.06
UV-Absorption (300 nm; 10 %; 1 cm; water)	≤ 0.02
UV-Absorption (400 nm; 10 %; 1 cm; water)	≤ 0.01
As (Arsenic)	≤ 0.0001 %
Ca (Calcium)	≤ 0.0010 %
Cd (Cadmium)	≤ 0.0001 %
Cu (Copper)	≤ 0.0001 %
Fe (Iron)	≤ 0.0001 %
Mg (Magnesium)	≤ 0.0010 %
Ni (Nickel)	≤ 0.00025 %
Pb (Lead)	≤ 0.0001 %
Zn (Zinc)	≤ 0.0002 %
Residual solvents (ICHQ3C) of class 2 (Methanol)	≤ 3000 ppm
Residual solvents (ICHQ3C) of class 2 (Nitromethane)	≤ 50 ppm
Residual solvents (ICHQ3C) of class 3 (Ethanol)	≤ 5000 ppm
Residual solvents (ICHQ3C) of class 3 (Ethylmethylketon)	≤ 5000 ppm
Other residual solvents (ICH Q3C)	excluded by manufacturing process
Sulfated ash	≤ 0.03
Loss on Drying (105°C)	≤ 0.5
Water (according to Karl Fischer)	≤ 0.5
Endotoxins	< 2.5
Total aerobic microbial count	≤ 10²
Total yeast and mould count	≤ 10²
Salmonella spp.	absent in 10 g
E.coli	absent in 1 g
Staphylococcus aureus	absent in 1 g
Pseudomonas aeruginosa	absent in 1 g
Candida albicans	absent in 1 g
Bile tolerante gram negative bacteria	absent in 1 g
DNases (Exo- and endonucleases)	not detected
Proteases	not detected
RNases	not detected
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).

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Merck 108219 Tris(hydroxymethyl)aminomethane hydrochloride EMPROVE® EXPERT 1 kg

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