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Sigma-Aldrich 130672 N-Hydroxysuccinimide 98% CAS No.: 6066-82-6 250 gr
Category
Brand
Stock Code
LB.SA.130672-250G
Kısa Bilgi
Synonym(s): 1-Hydroxy-2,5-pyrrolidinedione, HOSu, NHS Empirical Formula (Hill Notation): C4H5NO3 CAS Number: 6066-82-6 Molecular Weight: 115.09 Beilstein: 113913 EC Number: 228-001-3 MDL number: MFCD00005516 PubChem Substance ID: 24847975 NACRES: NA.22
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Sigma-Aldrich 130672 N-Hydroxysuccinimide 98% 250 gr
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Synonym(s): 1-Hydroxy-2,5-pyrrolidinedione, HOSu, NHS
Empirical Formula (Hill Notation): C4H5NO3
CAS Number: 6066-82-6
Molecular Weight: 115.09
Beilstein: 113913
EC Number: 228-001-3
MDL number: MFCD00005516
PubChem Substance ID: 24847975
NACRES: NA.22
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PROPERTIES
Assay 98%
form solid
mp 95-98 °C (lit.)
SMILES string ON1C(=O)CCC1=O
InChI 1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2
InChI key NQTADLQHYWFPDB-UHFFFAOYSA-N
DESCRIPTION
Application
N-Hydroxysuccinimide can be used in the synthesis of N-hydroxysuccinimide ester via dehydration reaction in the presence of dicyclohexylcarbodiimide in carboxylic acid.[1]
N-Hydroxysuccinimide has been used in the synthesis of intermediates such as:
- N
- -succinimidyl 3-(di-tert-butylfluorosilyl)benzoate[2]
- 4-[2,2-bis[(p-tolylsulfonyl)-methyl] acetyl]benzoic acid-NHS ester[3]
- N-succinimidyl 3-iodobenzoate[4]
It has also been used in a protocol for the surface modification of microchannels of a microfluidic-integrated surface plasmon resonance (SPR) platform for the detection and quantification of bacterial pathogens.[5]
Additive used in the carbodiimide method for improved amidations[6] and peptide couplings.[7]
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