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Sigma-Aldrich 377953 2-Chloro-1,3,2-dioxaphospholane 2-oxide 5 gr
Brand
Stock Code
LB.SA.377953-5G
Kısa Bilgi
Synonym(s): 2-Chloro-2-oxo-1,3,2-dioxaphospholane, Ethylene glycol chlorophosphate Empirical Formula (Hill Notation): C2H4ClO3P CAS Number: 6609-64-9 Molecular Weight: 142.48 Beilstein: 606582 EC Number: 229-560-6 MDL number: MFCD00043138 PubChem Substance ID: 24863533 NACRES: NA.22
Warranty Period
24 Month
| Sigma-Aldrich 377953 2-Chloro-1,3,2-dioxaphospholane 2-oxide 5 gr |
|
Synonym(s): 2-Chloro-2-oxo-1,3,2-dioxaphospholane, Ethylene glycol chlorophosphate
Empirical Formula (Hill Notation): C2H4ClO3P
CAS Number: 6609-64-9
Molecular Weight: 142.48
Beilstein: 606582
EC Number: 229-560-6
MDL number: MFCD00043138
PubChem Substance ID: 24863533
NACRES: NA.22 |
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PROPERTIES
form liquid
Quality Level 200
impurities <10% 2-Chloro-1,3,2-dioxaphospholane
refractive index n20/D 1.45 (lit.)
bp 89-91 °C/0.8 mmHg (lit.)
mp 12-14 °C (neat) (lit.)
density 1.55 g/mL at 25 °C (lit.)
storage temp. −20°C
SMILES string ClP1(=O)OCCO1
InChI 1S/C2H4ClO3P/c3-7(4)5-1-2-6-7/h1-2H2
InChI key SBMUNILHNJLMBF-UHFFFAOYSA-N
DESCRIPTION
General description
2-Chloro-1,3,2-dioxaphospholane 2-oxide (COP) is a cyclic chlorophosphate reagent[1] that can be prepared from 2-chloro-1,3,2-dioxaphospholane by reacting with molecular oxygen.[2]
Application
2-Chloro-1,3,2-dioxaphospholane 2-oxide may be used in the synthesis of:
- 2-methacryloyloxyethylphosphorylcholine[3]
- miltefosine (hexadecylphosphocholine, MT) analogs[4]
- phosphoric acid 2-trimethylamino-ethyl ester undec-10-enyl ester[5]
- uridine nucleolipid, (2′,3′-O-16-hentriacontanyliden-uridine-5′-phosphocholine, PUPC)[6]
adenosine nucleoamphiphile, (2′,3′-O-16-hentriacontanyliden-adenosine-5′-phosphocholine, PAPC)[6]
- structurally related phospholipids which are either conformationally restricted or flexible[7]
- phosphatidylcholines[8][9]
Reactant for:
- Synthesis of amino-functionalized hybrid hydrocarbon/fluorocarbon double-chain phospholipid
- Synthesis of UV-polymerizable lipids via Chabrier reaction
- Syntheses of block copolymers of poly(aliphatic ester) with clickable polyphosphoester
- Imprinting molecular recognition sites on multiwalled carbon nanotubes surface for electrochemical detection of insulin in real samples
- Synthesis of a zwitterionic silane
- Synthesis of a core-shell-corona micelle stabilized by reversible cross-linkage for intracellular drug delivery |
