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Sigma-Aldrich 390585 Suberohydroxamic acid 95% 1 gr
Category
Brand
Stock Code
LB.SA.390585-1G
Kısa Bilgi
Synonym(s): N,N′-Dihydroxyoctanediamide, SBHA, Suberoyl bis-hydroxamic acid Linear Formula: [-(CH2)3CONHOH]2 CAS Number: 38937-66-5 Molecular Weight: 204.22 MDL number: MFCD00192455 PubChem Substance ID: 24864150 NACRES: NA.22
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Sigma-Aldrich 390585 Suberohydroxamic acid 95% 1 gr |
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Synonym(s): N,N′-Dihydroxyoctanediamide, SBHA, Suberoyl bis-hydroxamic acid
Linear Formula: [-(CH2)3CONHOH]2
CAS Number: 38937-66-5
Molecular Weight: 204.22
MDL number: MFCD00192455
PubChem Substance ID: 24864150
NACRES: NA.22 |
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PROPERTIES
Quality Level 100
Assay 95%
mp 153-155 °C (lit.)
SMILES string ONC(=O)CCCCCCC(=O)NO
InChI 1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)
InChI key IDQPVOFTURLJPT-UHFFFAOYSA-N
DESCRIPTION
Packaging
1, 5 g
Biochem/physiol Actions
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells. |
