Sigma-Aldrich 81271 Polymyxin B solution 1 mg/mL in H2O, analytical standard CAS No.: 1405-20-5 10 mL
Brand
Stock Code
LB.SA.81271-10ML
Kısa Bilgi
CAS Number: 1405-20-5 MDL number: MFCD00131991 UNSPSC Code: 41116107 NACRES: NA.24
| Sigma-Aldrich 81271 Polymyxin B solution 1 mg/mL in H2O, analytical standard 10 mL |
| CAS Number: 1405-20-5 MDL number: MFCD00131991 UNSPSC Code: 41116107 NACRES: NA.24 |
|
PROPERTIES
grade analytical standard
Quality Level 100 concentration 1 mg/mL in H2O technique(s) HPLC: suitable gas chromatography (GC): suitable antibiotic activity spectrum Gram-negative bacteria Gram-positive bacteria fungi application(s) pharmaceutical (small molecule) format single component solution Mode of action cell membrane | interferes storage temp. 2-8°C SMILES string [S](=O)(=O)(O)O.N1CCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1=O) CCO)CCN)CCN)CC(C)C)Cc2ccccc2)CCN)NC(=O)C(NC(=O)C(NC(=O)C(NC=O)CCN)CCO)CCN InChI 1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4) DESCRIPTION General description Chemical structure: peptide Polymyxin B solution can find therapeutic applications as an antimicrobial agent, since it shows activity against multidrug-resistant (MDR) gram-negative bacterial infections.[1] Application Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots. Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. Biochem/physiol Actions Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane. Mode of Resistance: The activity of Polymyxin B sulfate is inhibited by iron(II), Co(II), Mn(II) and Magnesium ions. Polymyxin B may also be incompaitible with other microbial agents, including amphoterecin, cephalothin sodium, cephasolin sodium and heparin sodium. Antimicrobial Spectrum: Has bactericidal action on most gram-negative bacilli, including E. Coli and on most fungi and gram-positive bacteria. Preparation Note This product is concentrated at 1 mg/mL in water, and should be stored at 2-8°C. |
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