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Sigma-Aldrich H1635 N-Hippuryl-His-Leu hydrate powder, ≥98% (HPLC) 25 mg
Brand
Stock Code
LB.SA.H1635-25MG
| Sigma-Aldrich H1635 N-Hippuryl-His-Leu hydrate powder, ≥98% (HPLC) 25 mg |
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Synonym(s): N-Benzoyl-Gly-His-Leu, N-Hippuryl-L-histidyl-L-leucine hydrate
Empirical Formula (Hill Notation): C21H27N5O5 · xH2O
CAS Number: 207386-83-2
Molecular Weight: 429.47 (anhydrous basis)
Beilstein: 5664178
EC Number: 250-597-9
MDL number: MFCD00149318
PubChem Substance ID: 24895469
NACRES: NA.32
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PROPERTIES
Quality Level 200
assay ≥98% (HPLC)
form powder
color white to off-white
solubility acetic acid: ~50 mg/mL
storage temp. −20°C
SMILES string O.CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)c2ccccc2)C(O)=O
InChI 1S/C21H27N5O5.H2O/c1-13(2)8-17(21(30)31)26-20(29)16(9-15-10-22-12-24-15)25-18(27)11-23-19(28)14-6-4-3-5-7-14;/h3-7,10,12-13,16-17H,8-9,11H2,1-2H3,(H,22,24)(H,23,28)(H,25,27)(H,26,29)(H,30,31);1H2/t16-,17-;/m0./s1
InChI key NWOJMNXIJBZMPK-QJHJCNPRSA-N
Gene Information human... ACE(1636), ACE2(59272), mouse... ACE3(217246), rat... ACE(11421), ACE2(70008), ACE3(498012)
DESCRIPTION
Amino Acid Sequence
NBz-Gly-His-Leu
Application
N-Hippuryl-His-Leu hydrate has been used in the measurement of angiotensin-converting enzyme (ACE) inhibitory activity using oyster hydrolysates[1], semimembranosus muscle samples[2], and rabbit lung acetone powder.[3]
Packaging
25, 100, 500 mg in poly bottle
1 g in poly bottle
Biochem/physiol Actions
N-Hippuryl-His-Leu hydrate (HHL) can be used as an artificial substrate for angiotensin-converting enzyme (ACE).[4]
Substrates
Substrate for angiotensin converting enzyme. |