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Sigma-Aldrich I6634 Insulin from bovine pancreas powder, BioReagent, suitable for cell culture 50 mg
Brand
Stock Code
LB.SA.I6634-50MG
Kısa Bilgi
Synonym(s): Bovine insulin, Cell culture grade insulin Empirical Formula (Hill Notation): C254H377N65O75S6 CAS Number: 11070-73-8 Molecular Weight: 5733.49 EC Number: 234-291-2 MDL number: MFCD00131380 NACRES: NA.77
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Sigma-Aldrich I6634 Insulin from bovine pancreas powder, BioReagent, suitable for cell culture 50 mg |
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Synonym(s): Bovine insulin, Cell culture grade insulin
Empirical Formula (Hill Notation): C254H377N65O75S6
CAS Number: 11070-73-8
Molecular Weight: 5733.49
EC Number: 234-291-2
MDL number: MFCD00131380
NACRES: NA.77
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PROPERTIES
product line BioReagent
Quality Level 200
form powder
potency ≥25 USP units per mg
technique(s) cell culture | mammalian: suitable
solubility acetic acid: 2 mg/mL (pH: 2-3), hydrochloric acid: 2 mg/mL (pH: 2-3)
UniProt accession no. P01317
shipped in ambient
storage temp. −20°C
InChI key IXIBAKNTJSCKJM-BUBXBXGNSA-N
Gene Information cow ... INS(280829)
DESCRIPTION
Application
Insulin is used as a growth factor in many mammalian cell culture systems.
Insulin from bovine pancreas has been used for the differentiation of MSCs (mesenchymal stem cells) to adipocytes.[1]
It has been used for culturing of various cells.[2][3][4]
It has also been used to study insulin-mediated inhibition of the HMGCS2 (3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase) gene.[5]
Packaging
50, 100, 250, 500 mg in poly bottle
1 g in poly bottle
Biochem/physiol Actions
Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da.
The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond.
Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown
of glycogen, protein, and fat.
1 Physical form
powder-0 °C; solution stable 2-8 °C, 1 year
Reconstitution
Insulin has low solubility at neutral pH. It can be solubilized at 2 mg/ml in dilute acetic or hydrochloric acid, pH 2-3. |
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