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Sigma Aldrich SML1609 Ferutinin ≥98% (HPLC) CAS No.: 41743-44-6 5 mg
Category
Brand
Stock Code
LB.SA.SML1609-5MG
Kısa Bilgi
Synonym(s): 4-Hydroxy-benzoic acid (3R,3aS,4S,8aR)-1,2,3,3a,4,5,8,8a-octahydro-3-hydroxy-6,8a-dimethyl-3-(1-methylethyl)-4-azulenyl ester, 4-Oxy-6-(4-oxybenzoyloxy)dauc-8,9-en, Ferutinine, Tefestrol Empirical Formula (Hill Notation): C22H30O4 CAS Number: 41743-44-6 Molecular Weight: 358.47 UNSPSC Code: 51111800 PubChem Substance ID: 329825495 NACRES: NA.77
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CAS Number: 41743-44-6
| Sigma Aldrich SML1609 Ferutinin ≥98% (HPLC) CAS No.: 41743-44-6 5 mg |
| Synonym(s): 4-Hydroxy-benzoic acid (3R,3aS,4S,8aR)-1,2,3,3a,4,5,8,8a-octahydro-3-hydroxy-6,8a-dimethyl-3-(1-methylethyl)-4-azulenyl ester, 4-Oxy-6-(4-oxybenzoyloxy)dauc-8,9-en, Ferutinine, Tefestrol Empirical Formula (Hill Notation): C22H30O4 CAS Number: 41743-44-6 Molecular Weight: 358.47 UNSPSC Code: 51111800 PubChem Substance ID: 329825495 NACRES: NA.77 |
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PROPERTIES
Quality Level 100
Assay ≥98% (HPLC) form powder storage condition protect from light color white to beige storage temp. 2-8°C SMILES string CC1=CC[C@](CC[C@@]2(O)C(C)C)(C)[C@@]2([H])[C@@H](OC(C3=CC=C(O)C=C3)=O)C1 InChI 1S/C22H30O4/c1-14(2)22(25)12-11-21(4)10-9-15(3)13-18(19(21)22)26-20(24)16-5-7-17(23)8-6-16/h5-9,14,18-19,23,25H,10-13H2,1-4H3/t18-,19+,21-,22+/m0/s1 InChI key CYSHNJQMYORNJI-YUVXSKOASA-N DESCRIPTION General description Ferutinin, a daucane phytoestrogen, is found in the Ferula genus.[1][2] It is a natural terpenoid and a calcium ionophore.[3] Biochem/physiol Actions Ferutinin can suppress tumor development without causing systemic toxicity in various tumor cells and animal cancer models. It possesses estrogenic properties and a protective role against uterine carcinoma. Ferutinin exhibits anti-cancer action in estrogen-dependent breast cancer cells.[1] Ferutinin is a strong agonist for estrogen receptor (ER)α and agonist/antagonist for Erβ with IC50 values of 33.1 nM for ERα and 180.5 nM for Erβ. It has been shown to have both ionophoretic and apoptotic properties. It increases calcium permeability in the lipid bilayer and has been shown to improve bone regeneration in a rat study. It caused significant regression in tumor size in a mouse colon cancer model. |