Sigma-Aldrich S0252 Sulfobromophthalein disodium salt hydrate used to study hepatocyte transport functions 5 gr
Kategori
Marka
Stok Kodu
LB.SA.S0252-5G
Kısa Bilgi
Synonym(s): BSP, Bromsulfalein sodium disodium salt hydrate Empirical Formula (Hill Notation): C20H8Br4Na2O10S2 · xH2O CAS Number: 123359-42-2 Molecular Weight: 838.00 (anhydrous basis) EC Number: 200-761-0 MDL number: MFCD00150017 PubChem Substance ID: 24899433 NACRES: NA.47
| Sigma-Aldrich S0252 Sulfobromophthalein disodium salt hydrate |
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Synonym(s): BSP, Bromsulfalein sodium disodium salt hydrate
Empirical Formula (Hill Notation): C20H8Br4Na2O10S2 · xH2O
CAS Number: 123359-42-2
Molecular Weight: 838.00 (anhydrous basis)
EC Number: 200-761-0
MDL number: MFCD00150017
PubChem Substance ID: 24899433
NACRES: NA.47
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PROPERTIES
Quality Level 200
solubility water: 50 mg/mL, clear to hazy
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp. room temp
SMILES string [Na+].[Na+].[H]O[H].Oc1ccc(cc1S([O-])(=O)=O)C2(OC(=O)c3c(Br)c(Br)c(Br)c(Br)c23)c4ccc(O)c(c4)S([O-])(=O)=O
InChI 1S/C20H10Br4O10S2.2Na.H2O/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;;1H2/q;2*+1;/p-2
InChI key CDTNUNQQEUGDSD-UHFFFAOYSA-L
DESCRIPTION
Application
Sulfobromophthalein disodium salt hydrate has been used as a positive control to study the interaction of 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA) with organic anion transporter OATP1B3.[1]
Biochem/physiol Actions
Sulfobromophthalein (BSP) is a high affinity organic ion[2] substrate for organic anion transporting polypeptides (OATPs)[3] and has been used as a substrate for multidrug resistance associated protein 2 (Mrp2).[4] BSP is transported into hepatocytes by OATPs and, after conjugation to glutathione, is excreted into bile by Mrp2. It was found to inhibit the aldo-keto reductase ARK1C20.
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