Sigma-Aldrich SML4230 Cannabigerol ≥98% (HPLC), powder, CB1R and CB2R receptor agonist CAS No.: 25654-31-3 25 gr
Sigma-Aldrich SML4230 Cannabigerol
≥98% (HPLC), powder, CB1R and CB2R receptor agonist
Cannabigerol (CBG) is a non-psychoactive phytocannabinoid used in biochemical and pharmacological research. It interacts with cannabinoid receptors CB1 (CB1R) and CB2 (CB2R) and exhibits partial agonist activity at both receptor subtypes.
Sigma-Aldrich SML4230 is supplied as a powder with an assay of ≥98% by HPLC. It is intended for laboratory research applications involving cannabinoid receptor interactions and related biological pathways.
Product Highlights
Assay: ≥98% (HPLC)
Form: Powder
Color: White to beige
Biological activity: CB1R and CB2R partial agonist
CAS Number: 25654-31-3
Molecular Formula: C21H32O2
Molecular Weight: 316.48 g/mol
Storage Temperature: -25… -10 °C
Technical Specifications
| Parameter | Specification |
|---|---|
| Brand | Sigma-Aldrich |
| Product Name | Cannabigerol |
| Product Number | SML4230 |
| Synonym | CBG |
| CAS Number | 25654-31-3 |
| Empirical Formula | C21H32O2 |
| Molecular Weight | 316.48 g/mol |
| MDL Number | MFCD00869599 |
| Assay | ≥98% (HPLC) |
| Form | Powder |
| Color | White to beige |
| Solubility | DMSO: 2 mg/mL, clear |
| Storage Temperature | -25… -10 °C |
| Quality Level | 100 |
| NACRES | NA.21 |
Biochemical and Physiological Actions
Cannabigerol is a non-psychoactive phytocannabinoid that binds to cannabinoid CB1 and CB2 receptors with reported Ki values of 440 nM and 337 nM, respectively.
It acts as a partial agonist at CB1R and CB2R receptor subtypes. Cannabigerol also exhibits potent alpha-2-adrenoceptor agonist activity with a reported EC50 value of 0.2 nM.
Cannabigerol has been investigated for its influence on inflammatory signaling proteins, redox balance, neuromodulatory pathways, and antimicrobial responses.
These properties are relevant to experimental pharmacology and biochemical research. They do not establish clinical efficacy or suitability for therapeutic use.
Applications
Cannabinoid receptor research: Investigation of ligand binding and activation at CB1 and CB2 receptors.
Pharmacological studies: Evaluation of partial agonist activity and receptor-mediated biological responses.
Receptor complex research: Studies involving CB1–CB2 heteroreceptor complexes.
Inflammatory signaling research: Experimental investigations of signaling pathways and inflammatory mediators.
Biochemical research: Investigation of cellular and molecular effects associated with cannabigerol.
Chemical Identification
| Chemical Name | Cannabigerol |
| Synonyms | CBG; 2-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-5-pentyl-1,3-benzenediol |
| CAS Number | 25654-31-3 |
| Molecular Formula | C21H32O2 |
| Molecular Weight | 316.48 g/mol |
| MDL Number | MFCD00869599 |
Safety and Storage Information
Signal Word: Warning
H302: Harmful if swallowed.
H361d: Suspected of damaging the unborn child.
Hazard Classification: Acute Toxicity Category 4 (oral); Reproductive Toxicity Category 2.
Storage Class: 11 – Combustible Solids
Water Hazard Class: WGK 3
Storage Temperature: -25… -10 °C
Consult the current manufacturer Safety Data Sheet (SDS) for complete hazard, handling, storage, and disposal requirements.
Available Product Sizes
| Product Number | Size |
|---|---|
| SML4230-5MG | 5 mg |
| SML4230-25MG | 25 mg |
Frequently Asked Questions
What is the purity of Sigma-Aldrich SML4230?
The product has an assay of ≥98% as determined by HPLC.
What is the CAS number of Cannabigerol?
The CAS number is 25654-31-3.
What is the physical form?
Powder, white to beige in color.
What is the storage temperature?
The manufacturer specifies storage at -25… -10 °C.
Does Cannabigerol interact with CB1 and CB2 receptors?
Yes. Cannabigerol exhibits partial agonist activity at both receptor subtypes.
Is SML4230 intended for human use?
No. It is a laboratory research chemical and is not intended for human consumption, clinical administration, or therapeutic use.
Technical Documents and Certificates
Official Sigma-Aldrich SML4230 Product Information
Safety Data Sheets (SDS), Certificates of Analysis (CoA), and Certificates of Origin (CoO) can be accessed through the manufacturer documentation section, where available.
Research Use and Regulatory Information
This product is intended for qualified laboratory research applications only.
Local regulatory restrictions concerning cannabinoids may apply. Possession, distribution, importation, and use must comply with all applicable national requirements.
For technical documentation and product information, contact Labor Teknik AŞ.
Product Information and Technical Support
Product: Sigma-Aldrich SML4230 Cannabigerol ≥98% (HPLC)
Catalogue Number: SML4230
CAS Number: 25654-31-3
For technical documentation and regulatory information, contact Labor Teknik AŞ.